287815 | 3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem

287815
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₄Cl₂O₂ 51050-59-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      287815-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.
          Effective concentration: 5-100 µM; t½ = 20 min at pH 7.5.
          Catalogue Number287815
          Brand Family Calbiochem®
          References
          ReferencesCain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
          Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
          Odake, S., et al. 1991. Biochemistry 30, 2217.
          Harper, J.W., et al. 1985. Biochemistry 24, 1831.
          Product Information
          CAS number51050-59-0
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₉H₄Cl₂O₂
          Chemical formulaC₉H₄Cl₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetserine proteases
          Primary Target IC<sub>50</sub>5-100 µM
          Purity≥99% by elemental analysis
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          287815

          References

          Reference overview
          Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
          Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
          Odake, S., et al. 1991. Biochemistry 30, 2217.
          Harper, J.W., et al. 1985. Biochemistry 24, 1831.

          Citations

          Title
        • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-June-2008 RFH
          DescriptionA potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 µM.
          FormWhite lyophilized solid
          CAS number51050-59-0
          Chemical formulaC₉H₄Cl₂O₂
          Structure formulaStructure formula
          Purity≥99% by elemental analysis
          SolubilityDMF (10 mM) or DMSO (10 mM)
          Storage +2°C to +8°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
          Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
          Odake, S., et al. 1991. Biochemistry 30, 2217.
          Harper, J.W., et al. 1985. Biochemistry 24, 1831.
          Citation
        • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.