203984 2,3-Butanedione 2-Monoxime - CAS 57-71-6 - Calbiochem

203984
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄H₇NO₂ 57-71-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203984-500MG
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          Plastic ampoule 500 mg
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          Description
          OverviewAn inhibitor of skeletal and cardiac muscle contraction. A general reversible inhibitor of myosin ATPase in eukaryotes. A “chemical phosphatase,” which dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC50 = 18.3 nM). Also shown to induce Ca2+ release from canine cardiac sarcoplasmic reticulum (SR).
          Catalogue Number203984
          Brand Family Calbiochem®
          SynonymsBDM
          References
          ReferencesPhillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun. 229, 154.
          Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol. 74, 305.
          Zhu, Y., and Ikeda, S.R. 1993. Neurosci. Lett. 155, 24.
          Product Information
          CAS number57-71-6
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₄H₇NO₂
          Chemical formulaC₄H₇NO₂
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCa2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
          Primary Target IC<sub>50</sub>18.3 nM inhibiting Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
          Purity≥98% by GC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSEK3150000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203984

          References

          Reference overview
          Phillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun. 229, 154.
          Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol. 74, 305.
          Zhu, Y., and Ikeda, S.R. 1993. Neurosci. Lett. 155, 24.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-October-2017 JSW
          SynonymsBDM
          DescriptionAn inhibitor of skeletal and cardiac muscle contraction. A "chemical phosphatase" that dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC50 = 18.3 nM). Also shown to induce Ca2+ release from canine cardiac sarcoplasmic reticulum (SR).
          FormWhite to off-white solid
          CAS number57-71-6
          RTECSEK3150000
          Chemical formulaC₄H₇NO₂
          Structure formulaStructure formula
          Purity≥98% by GC
          SolubilityMethanol (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPhillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun. 229, 154.
          Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol. 74, 305.
          Zhu, Y., and Ikeda, S.R. 1993. Neurosci. Lett. 155, 24.