100069 | 17-DMAG - CAS 467214-21-7 - Calbiochem

100069
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₄₈N₄O₈ • HCl 467214-21-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      100069-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.
          Catalogue Number100069
          Brand Family Calbiochem®
          SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
          References
          ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
          Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
          Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
          Product Information
          CAS number467214-21-7
          ATP CompetitiveN
          FormPurple solid
          Hill FormulaC₃₂H₄₈N₄O₈ • HCl
          Chemical formulaC₃₂H₄₈N₄O₈ • HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Application17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM).
          Biological Information
          Primary Target17-DMAG
          Primary Target IC<sub>50</sub>GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          100069

          References

          Reference overview
          Tian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
          Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
          Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
          DescriptionA cell-permeable, water soluble, potent anti-tumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen).
          FormPurple solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number467214-21-7
          Chemical formulaC₃₂H₄₈N₄O₈ • HCl
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO (5 mg/ml) or H₂O (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
          Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
          Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.