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100068 | 17-AAG - CAS 75747-14-7 - Calbiochem

100068
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₄₃N₃O₈ 75747-14-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      100068-500UG
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          Glass bottle 500 μg
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          Description
          OverviewA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53 (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression.
          Catalogue Number100068
          Brand Family Calbiochem®
          SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
          References
          ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
          Clarke, P.A., et al. 2002. Oncogene 19, 4125.
          Clarke, P.A., et al. 2000. Oncogene 19, 4125.
          Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
          Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
          Product Information
          CAS number75747-14-7
          ATP CompetitiveN
          FormPurple solid
          Hill FormulaC₃₁H₄₃N₃O₈
          Chemical formulaC₃₁H₄₃N₃O₈
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetHsp90
          Primary Target IC<sub>50</sub>EC50 = 7.2 µM for Hsp90
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          100068

          References

          Reference overview
          Basso, A.D., et al. 2002. Oncogene 21, 1159.
          Clarke, P.A., et al. 2002. Oncogene 19, 4125.
          Clarke, P.A., et al. 2000. Oncogene 19, 4125.
          Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
          Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
          DescriptionA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Reported to induce apoptosis and exhibit anti-tumor properties (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53, (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt. Hence, inhibits the Ras/Raf/MEK and PI3-Kinase signaling pathways. Shown to sensitize cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380), and down-regulates vascular endothelial factor expression.
          FormPurple solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number75747-14-7
          Chemical formulaC₃₁H₄₃N₃O₈
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
          Clarke, P.A., et al. 2002. Oncogene 19, 4125.
          Clarke, P.A., et al. 2000. Oncogene 19, 4125.
          Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
          Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Heat Shock Protein Inhibitors