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100081 | 14-3-3 Antagonist I, 2-5 - Calbiochem

100081
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₂₃N₆O₈P

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      100081-5MG
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      Stocked 
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      Available
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable dipeptidyl-phosphoserine compound that effectively disrupts 14-3-3 interaction with its ligands (IC50 = 2.6 µM against TMR-GG-RLSHpSSLPG binding to human 14-3-3ς), including Raf-1 and p53. Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (100µM) in a time-dependent manner.
          Catalogue Number100081
          Brand Family Calbiochem®
          Synonyms(S)-2-(2-(4-Azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl-dihydrogen phosphate
          References
          ReferencesWu, H., et al. 2010. Angew. Chem. Int. Ed. 49, 6528.
          Product Information
          FormPale yellow to beige solid
          Hill FormulaC₂₀H₂₃N₆O₈P
          Chemical formulaC₂₀H₂₃N₆O₈P
          Hygroscopic Hygroscopic
          Structure formula Image
          Applications
          Biological Information
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          100081

          References

          Reference overview
          Wu, H., et al. 2010. Angew. Chem. Int. Ed. 49, 6528.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-March-2012 JSW
          Synonyms(S)-2-(2-(4-Azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl-dihydrogen phosphate
          DescriptionA cell-permeable dipeptidyl-phosphoserine compound that targets 14-3-3 phosphopeptide binding site and effectively competes against 14-3-3 ligands, including Raf-1 and p53, binding to 14-3-3 (IC50 = 2.6 µM against TMR-GG-RLSHpSSLPG binding to human 14-3-3ς). Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (live cell population after 12 h 100 µM drug treatment = 30% of control). Stability study using A549 cell lysates (100 µM drug in 1 µg/ml lysate) reveals a dephosphorylation t1/2 of ~ 6 hrs and no detectable proteolytic degradation up to 12 hrs.
          FormPale yellow to beige solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₀H₂₃N₆O₈P
          Structure formula
          Purity≥90% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWu, H., et al. 2010. Angew. Chem. Int. Ed. 49, 6528.