385581 | 11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

385581
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₃₃BrN₂O₃ 1009373-58-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      385581-10MG
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          10 mg
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          Description
          OverviewA cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.
          Catalogue Number385581
          Brand Family Calbiochem®
          References
          ReferencesTice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
          Product Information
          CAS number1009373-58-3
          FormWhite solid
          Hill FormulaC₂₆H₃₃BrN₂O₃
          Chemical formulaC₂₆H₃₃BrN₂O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          385581

          References

          Reference overview
          Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          DescriptionA cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10 mg/kg in animals p.o.) results in an ~80% reduction in the concentration of plasma cortisol over vehicle treated controls.
          FormWhite solid
          CAS number1009373-58-3
          Chemical formulaC₂₆H₃₃BrN₂O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSL (100 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesTice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.