149101 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ACPC

Primary Target: Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
149101
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄H₇NO₂ 22059-21-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      149101-1GM
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          		 Glass bottle 1 gm
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          149101-250MG
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              		 Glass bottle 250 mg
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              Description
              OverviewAn agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3H-glycine binding to rat forebrain membrane (IC50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC50 = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
              Catalogue Number149101
              Brand Family Calbiochem®
              SynonymsACPC
              References
              ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
              Zapata, A., et al. 1996. NeuroReport 7, 397.
              Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
              Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
              Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
              Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
              Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.
              Product Information
              CAS number22059-21-8
              ATP CompetitiveN
              FormCrystalline solid
              Hill FormulaC₄H₇NO₂
              Chemical formulaC₄H₇NO₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Application1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
              Biological Information
              Primary TargetGlycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
              Primary Target IC<sub>50</sub>38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
              Purity≥ 98% by TLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSGZ1110000
              Safety Information
              R PhraseR: 36/37/38

              Irritating to eyes, respiratory system and skin.
              S PhraseS: 26-36

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage +15°C to +30°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              149101

              References

              Reference overview
              Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
              Zapata, A., et al. 1996. NeuroReport 7, 397.
              Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
              Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
              Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
              Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
              Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

              Brochure

              Title
              Excitotoxic Glutamate Analogs Technical Bulletin
              Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision10-April-2008 RFH
              SynonymsACPC
              DescriptionA potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks 3H-glycine binding to rat forebrain membranes (IC50 = 38 nM).
              FormCrystalline solid
              CAS number22059-21-8
              RTECSGZ1110000
              Chemical formulaC₄H₇NO₂
              Structure formulaStructure formula
              Purity≥ 98% by TLC
              SolubilityH₂O (40 mg/ml). May require heating and sonication to achieve complete solubilization.
              Storage +15°C to +30°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Irritant
              ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
              Zapata, A., et al. 1996. NeuroReport 7, 397.
              Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
              Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
              Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
              Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
              Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.