565773 γ-Secretase Inhibitor XII - Calbiochem

565773
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₃₀N₂O₄

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565773-5MG
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      Stocked 
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
          Catalogue Number565773
          Brand Family Calbiochem®
          SynonymsZ-IL-CHO
          References
          ReferencesWeijzen, S., et al. 2002. Nat. Med. 8, 979.
          McLendon, C., et al. 2000. FASEB J. 14, 2383.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₀H₃₀N₂O₄
          Chemical formulaC₂₀H₃₀N₂O₄
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Applicationγ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in APP695 expressing CHO 2b-7 cells.
          Biological Information
          Primary TargetAβ40 in vitro
          Primary Target IC<sub>50</sub>7.9 µM for Aβ40; 7.6 µM for Aβ42 in vitro
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Ile-Leu-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          γ-Secretase Inhibitor XII - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          γ-Secretase Inhibitor XII - Calbiochem Certificates of Analysis

          TitleLot Number
          565773

          References

          Reference overview
          Weijzen, S., et al. 2002. Nat. Med. 8, 979.
          McLendon, C., et al. 2000. FASEB J. 14, 2383.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-September-2008 RFH
          SynonymsZ-IL-CHO
          DescriptionA cell-permeable, reversible dipeptide aldehyde that reduces amyloid-β protein (Aβ) production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured cells that stably over-express APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also shown to block the generation of γCTF (γ-secretase-generated carboxy-terminal fragment).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₀H₃₀N₂O₄
          Peptide SequenceZ-Ile-Leu-CHO
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWeijzen, S., et al. 2002. Nat. Med. 8, 979.
          McLendon, C., et al. 2000. FASEB J. 14, 2383.