565770 γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem

565770
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₂₆F₂N₂O₄ 208255-80-5

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565770-10MG
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          Plastic ampoule 10 mg
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          565770-5MG
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              Glass bottle 5 mg
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              Description
              OverviewA cell-permeable dipeptide that suppresses Aβ production by blocking γ-secretase (Aβtotal IC50 = 115 nM, Aβ42 IC50 = 200 nM). Prevents Aβ34 generation in murine N2a cells and hAPP/hBACE-1 transfected human HEK 293 cells. Reported to be functionally active in both HEK 293 cells and neuronal cultures without affecting the secretion of amyloid-β precursor protein (APP). Also shown to lower Aβ levels acutely in APP-transgenic mice. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice. A 25 mM (5 mg/462 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565784) in DMSO is also available.
              Catalogue Number565770
              Brand Family Calbiochem®
              SynonymsDAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
              References
              ReferencesMorohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670.
              Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555.
              Oddo, S., et al. 2004. Neuron 43, 321.
              Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
              Sastre, M., et al. 2001. EMBO Rep. 2, 835.
              Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
              Product Information
              CAS number208255-80-5
              ATP CompetitiveN
              FormLyophilized
              Hill FormulaC₂₃H₂₆F₂N₂O₄
              Chemical formulaC₂₃H₂₆F₂N₂O₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targettotal
              Primary Target IC<sub>50</sub>115 nM suppressing Aβtotal production; 200 nM suppressing Aβ42 production
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem Certificates of Analysis

              TitleLot Number
              565770

              References

              Reference overview
              Morohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670.
              Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555.
              Oddo, S., et al. 2004. Neuron 43, 321.
              Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
              Sastre, M., et al. 2001. EMBO Rep. 2, 835.
              Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

              Citations

              Title
            • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
            • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision12-November-2007 JSW
              SynonymsDAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
              DescriptionA cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC50 = 115 nM; Aβ42 IC50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of an ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP695. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
              FormLyophilized
              Intert gas (Yes/No) Packaged under inert gas
              CAS number208255-80-5
              Chemical formulaC₂₃H₂₆F₂N₂O₄
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (20 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesMorohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670.
              Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555.
              Oddo, S., et al. 2004. Neuron 43, 321.
              Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
              Sastre, M., et al. 2001. EMBO Rep. 2, 835.
              Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
              Citation
            • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
            • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.