565788 β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

565788
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₃₈N₄O₅S 797035-11-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565788-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 565794).

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number565788
          Brand Family Calbiochem®
          SynonymsBACE Inhibitor C3
          References
          ReferencesHalima, S.B., et al. 2016. Cell Reports. 14, In press.
          Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.
          Product Information
          CAS number797035-11-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₁H₃₈N₄O₅S
          Chemical formulaC₃₁H₃₈N₄O₅S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Application CommentsSolubilize in DMSO (10 mg/ml), aliquot & store at -20*C; stable for 3 months.
          Biological Information
          Primary TargetBACE-1 human
          Primary Target IC<sub>50</sub>15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          565788

          References

          Reference overview
          Halima, S.B., et al. 2016. Cell Reports. 14, In press.
          Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.

          Brochure

          Title
          Calbiochem Biologics 32.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-February-2014 JSW
          SynonymsBACE Inhibitor C3
          DescriptionA cell-permeable and potent inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 230 nM, 7.6 µM and > 50 µM for BACE-2, cathepsin D, and renin, respectively).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number797035-11-1
          Chemical formulaC₃₁H₃₈N₄O₅S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          CommentsSolubilize in DMSO (10 mg/ml), aliquot & store at -20*C; stable for 3 months.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHalima, S.B., et al. 2016. Cell Reports. 14, In press.
          Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.