565749 β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem

565749
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₃₉N₃O₅ 263563-09-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565749-1MG
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          Plastic ampoule 1 mg
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          565749-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.
              Catalogue Number565749
              Brand Family Calbiochem®
              SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
              References
              ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
              Product Information
              CAS number263563-09-3
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₂₅H₃₉N₃O₅
              Chemical formulaC₂₅H₃₉N₃O₅
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targetβ-secretase
              Primary Target IC<sub>50</sub>700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceZ-Val-Leu-Leu-CHO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem Certificates of Analysis

              TitleLot Number
              565749

              References

              Reference overview
              Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision04-April-2011 RFH
              SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
              DescriptionA potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number263563-09-3
              Chemical formulaC₂₅H₃₉N₃O₅
              Peptide SequenceZ-Val-Leu-Leu-CHO
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.