487910 | (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem

487910
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₁₂N₂O₄S 79032-48-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      487910-1SET
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          Glass bottle 1 set
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          487910-20MG
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              Plastic ampoule 20 mg
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              Description
              OverviewNitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
              Catalogue Number487910
              Brand Family Calbiochem®
              SynonymsSNAP
              References
              ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
              Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
              Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
              Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
              Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
              Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
              Product Information
              CAS number79032-48-7
              ATP CompetitiveN
              FormPale green solid
              Hill FormulaC₇H₁₂N₂O₄S
              Chemical formulaC₇H₁₂N₂O₄S
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetNitric oxide donor
              Primary Target IC<sub>50</sub>EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 36/37/38

              Irritating to eyes, respiratory system and skin.
              S PhraseS: 26-36

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              487910

              References

              Reference overview
              Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
              Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
              Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
              Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
              Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
              Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.

              Brochure

              Title
              Nitric Oxide Donors and Scavengers Technical Bulletin
              Nitric Oxide and Oxidative Stress Brochure

              Citations

              Title
            • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision25-October-2016 JSW
              SynonymsSNAP
              DescriptionNitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
              FormPale green solid
              CAS number79032-48-7
              Chemical formulaC₇H₁₂N₂O₄S
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (25 mg/ml), Ethanol (25 mg/ml), or Methanol
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
              Toxicity Irritant
              ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
              Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
              Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
              Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
              Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
              Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
              Citation
            • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.