407293 | α-Interferon, Mouse, Recombinant, E. coli

407293
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407293-100KU
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      Stocked 
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          Plastic ampoule 100 ku
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          Description
          OverviewRecombinant, mouse α-interferon expressed in E. coli. Antiviral and anti-neoplastic agent. Suppresses bone marrow function and induces apoptotic cell death in non-melanoma skin cancer. IFN-α signaling is mediated by JAK1 and TYK2 tyrosine kinases. Note: 1 KU = 1000 units.
          Catalogue Number407293
          Brand Family Calbiochem®
          References
          ReferencesKrishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
          Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
          Dianzani, F. 1993. Gut 34, 574.
          Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
          Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
          Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
          Pestka, S. 1986. Methods Enzymol. 119, 14.
          Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
          Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
          Rubinstein, S., et al. 1981. J. Virol. 37, 755.
          Product Information
          Activity≥3.5 x 10⁴ units/ml
          Unit of DefinitionOne unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.
          FormLiquid
          FormulationIn PBS containing 0.1% BSA.
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407293

          References

          Reference overview
          Krishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
          Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
          Dianzani, F. 1993. Gut 34, 574.
          Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
          Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
          Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
          Pestka, S. 1986. Methods Enzymol. 119, 14.
          Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
          Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
          Rubinstein, S., et al. 1981. J. Virol. 37, 755.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-December-2008 JSW
          DescriptionRecombinant, mouse α-interferon expressed in E. coli. Antiviral, antineoplastic agent. Expressed during the triggering stage of macrophage cytocidal activation. Suppresses bone marrow function and cell proliferation. Modulates the immune response. Also known to induce apoptotic cell death in non-melanoma skin cancer.
          FormLiquid
          FormulationIn PBS containing 0.1% BSA.
          Purity≥95% by SDS-PAGE
          Activity≥3.5 x 10⁴ units/ml
          Unit definitionOne unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          Merck USA index14, 4990
          ReferencesKrishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
          Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
          Dianzani, F. 1993. Gut 34, 574.
          Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
          Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
          Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
          Pestka, S. 1986. Methods Enzymol. 119, 14.
          Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
          Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
          Rubinstein, S., et al. 1981. J. Virol. 37, 755.

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          Categories

          Life Science Research > Proteins and Enzymes > Other Proteins