203980 | α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

203980
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁ 11032-79-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203980-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewBlocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
          Catalogue Number203980
          Brand Family Calbiochem®
          References
          ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
          Zhang, Z.W., et al. 1994. Neuron 12, 167.
          Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
          Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
          Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
          Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
          Ruan, K.H., et al. 1990. 87, 6156.
          Product Information
          CAS number11032-79-4
          ATP CompetitiveN
          FormLyophilized solid
          Hill FormulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
          Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
          ReversibleN
          Applications
          Biological Information
          Primary TargetMotor end-plate acetylcholine receptor
          Primary Target IC<sub>50</sub>Kd = 1 pM to 1 nM for motor end-plate acetylcholine receptor
          Physicochemical Information
          Cell permeableN
          ContaminantsNone detectable by IEF. Supplied as an acetate salt
          Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSEI6201400
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203980

          References

          Reference overview
          Lopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
          Zhang, Z.W., et al. 1994. Neuron 12, 167.
          Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
          Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
          Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
          Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
          Ruan, K.H., et al. 1990. 87, 6156.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          DescriptionA polypeptide composed of 74 amino acids containing 5 disulfide bridges. Blocks neuromuscular transmission by irreversible binding to the motor end-plate acetylcholine receptor (Kd = 1 nM to 1 pM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced augmentation in intracellular Ca2+ in PC12 cells (IC50 = 310 nM). Prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-Bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 > 3 µM).
          FormLyophilized solid
          CAS number11032-79-4
          RTECSEI6201400
          Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
          Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
          ContaminantsNone detectable by IEF. Supplied as an acetate salt
          SolubilityH₂O or PBS
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 1488
          ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
          Zhang, Z.W., et al. 1994. Neuron 12, 167.
          Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
          Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
          Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
          Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
          Ruan, K.H., et al. 1990. 87, 6156.