203390 | (±)-Blebbistatin - CAS 674289-55-5 - Calbiochem

203390
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₆N₂O₂ 674289-55-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203390-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable compound that acts as a selective, potent, and reversible inhibitor of nonmuscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤ 100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly. A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203389) in 90% DMSO is also available.
          Catalogue Number203390
          Brand Family Calbiochem®
          References
          ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
          Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
          Straight, A.F., et al. 2003. Science 299, 1743.
          Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
          Product Information
          CAS number674289-55-5
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₈H₁₆N₂O₂
          Chemical formulaC₁₈H₁₆N₂O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetATPase
          Primary Target IC<sub>50</sub><100 µM inhibiting the ATPase and gliding motility of human platelets
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in 90% DMSO, aliquot and freeze (-20°C). Stock solutions in 90% DMSO are stable for up to 1 month at -20°C. Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203390

          References

          Reference overview
          Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
          Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
          Straight, A.F., et al. 2003. Science 299, 1743.
          Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          DescriptionA cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number674289-55-5
          Chemical formulaC₁₈H₁₆N₂O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Solubility100% DMSO (100 mg/ml), 90% DMSO (75 mg/ml) or Methanol (1.5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in 90% DMSO, aliquot and freeze (-20°C). Stock solutions in 90% DMSO are stable for up to 1 month at -20°C. Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
          ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
          Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
          Straight, A.F., et al. 2003. Science 299, 1743.
          Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.