Sterilizing-grade Durapore 0.1 µm and 0.22 µm Hydrophilic Cartridge Filters

A trusted name in the industry for over 25 years, The Durapore membrane contributes to clean processes due to low extractables, broad chemical compatibility, and its non-fiber releasing properties.

Durapore Cartridges

Overview

Specifications

Ordering Information

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Durapore 0.22 µm · Code 0, 2-222 O-ring Clear Sorting & Filtering
Catalog Numbericon Cartridge Nominal Length [in (cm)]icon
CVGL01TP310 (25) Show Pricing & Availability
CVGL02TP320 (50) Show Pricing & Availability
CVGL03TP330 (75) Show Pricing & Availability

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Durapore 0.22 µm · Code 5, 2-222 O-ring w/spear Clear Sorting & Filtering
Catalog Numbericon Cartridge Nominal Length [in (cm)]icon
CVGL51TP310 (25) Show Pricing & Availability
CVGL52TP320 (50) Show Pricing & Availability
CVGL53TP330 (75) Show Pricing & Availability

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Durapore 0.22 µm · Code 7, 2-226 O-ring w/bayonet and spear Clear Sorting & Filtering
Catalog Numbericon Cartridge Nominal Length [in (cm)]icon
CVGL71TP310 (25) Show Pricing & Availability
CVGL72TP320 (50) Show Pricing & Availability
CVGL73TP330 (75) Show Pricing & Availability
CVGL74TP340 (100) Show Pricing & Availability
CVGL75S015 (12.5) Show Pricing & Availability

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Durapore 0.1 µm · Code 0, 2-222 O-ring Clear Sorting & Filtering
Catalog Numbericon Cartridge Nominal Length [in (cm)]icon
CVVL01TP310 (25) Show Pricing & Availability
CVVL02TP320 (50) Show Pricing & Availability
CVVL03TP330 (75) Show Pricing & Availability

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Durapore 0.1 µm · Code 5, 2-222 O-ring w/spear Clear Sorting & Filtering
Catalog Numbericon Cartridge Nominal Length [in (cm)]icon
CVVL51TP310 (25) Show Pricing & Availability
CVVL52TP320 (50) Show Pricing & Availability
CVVL53TP330 (75) Show Pricing & Availability

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Durapore 0.1 µm · Code 7, 2-226 O-ring w/bayonet and spear Clear Sorting & Filtering
Catalog Numbericon Cartridge Nominal Length [in (cm)]icon
CVVL71TP310 (25) Show Pricing & Availability
CVVL72TP320 (50) Show Pricing & Availability
CVVL73TP330 (75) Show Pricing & Availability
CVVL75S015 (12.5) Show Pricing & Availability

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    Documentation

    Brochure

    Title
    Opticap XL and XLT Capsules Configuration Table

    Technical Info

    Title
    Bubble Point Ratio Determination for 60/40 and 70/30 IPA
    Bubble Point Ratio Determination for Vesphene IIse (1:128)
    Establishing Product Specific Bubble Point Specifications For Sterilizing-Grade (0.22 µm) Durapore Filters
    Millipore Steam Sterilization & Integrity Testing Procedures
    Minimum Bubble Point Specification for Sterilizing-Grade 0.22 µm Durapore Membranes
    Validation and Qualification for Durapore Sterilizing-Grade (0.22 µm) Membrane VMF4

    Data Sheet

    Title
    Sterile and Gamma Compatible Sterilizing-grade Durapore® 0.1 μm and 0.22 μm Filters
    Sterilizing-grade Durapore® 0.1 μm and 0.22 μm Hydrophilic Filters

    References

    Reference overview
    Evaluation of Recovery Filters for Use in Bacterial Retention Testing of Sterilizing-Grade Filters
    Carter, Jeff; Vol. 50, No.3 / May-June
    Vol. 50, No.3 / May-June 1996

    FAQ

    QuestionAnswer
    Can Durapore 0.22 micron cartridges be used in the reverse direction? Durapore filters are bidirectionally supported. If the filter is inadvertently used in the reverse direction, a post-use integrity test will identify whether or not the filter cartridge was integral during processing. The specification for theis filter is > 50.0 psi for a water bubble point test and < 13.3 ml/minute per 10"element for a diffusion test. If the filter passes this test, no damage occured during use.

    Please note that the maximum allowable pressure specification is different in the reverse direction - 50 psid vs. 80 psid in the forward direction.
    What are the most common causes of filter clogging (air bubbles, particulates, surface tension, inappropriate filter size etc.)? Trapped bubbles, particulates and improper sizing are all common causes of fitration issues. True filter clogging is caused by particulates. Hard particles will form a cake on the filter surface. This will generally slow the filtration but not necessarily block filtration becuase fluid can flow through the layer of hard particles and then through the filter.

    Deformable particles can compress across the filter pores, forming impermeable barriers to filtration. This type of problem is common with solutions containing proteins or lipids.
    What is the compatibility of Durapore with high pH solutions? The upper recommended pH limit for Durapore membranes is 10. At pH < 10, the hydrophilization layer of the membrane may become subject to hydrolysis. The extent of hydrolysis is a function of time, temperature , concentration and time of exposure. Upon exposure to high pH, the hydrophylization layer can swell which could result in a loss of permeability or flux. The hydrolysis of the hydrophilic layer will also lead to increased extractables from the membrane.
    What are Millipore's general recommendations for filtering high pH solutions? For applications involving pH > 10, Millipore recommends the use or our PES membranes Express SHF or Express SHC. For information on these filters :

    Express SHF: http://www.millipore.com/catalogue.nsf/docs/C8873
    Express SHC: http://www.millipore.com/catalogue.nsf/docs/C9146
    How can I differentiate filter plugging due to air bubbles, particulates, surface tension, inappropriate filter size, etc.? Air locking will occur when filtration is initiated without adequate venting or when air bubbles become trapped in fluid lines. Air will pass easily through a dry hydrophillic or hydrophobic filter. However, when a filter is wet and air is applied to a surface, the air will remain until it is manually moved upstream by venting or until the bubble point of the filter is reached. Bubble point is defined as the pressure at which gas displaces liquid for the largest set of filter pores and is able to flow through the pores. Air locking reduces the effective filtration area of the filter and thus reduces the flow rate.

    Surface tension refers to the strong cohesive forces present between molecules at the surface of a liquid. The higher the surface tension, the more force is required to force fluid through the membrane..

    Innapropriate filter size will can cause a filter to plug prematurely. Filter pore size is chosen based on the application. If the application requires a sterile fluid, than a 0.22 micron membrane would be used for standard solutions that have bacterial bioburden. A 0.1 micron filter would be used for applications where mycoplasma is a concern. Where virus contamination is a concern, ultrafiltration would be required. The selection of a filter pore size that is smaller than that required for the application will cause a decrease in filter capacity and an increase in cost.

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    Categories

    Biopharmaceutical Manufacturing > Downstream Processing > Sterile Filtration > Sterile Liquid > Durapore