505875 | (+)-Bicuculline - CAS 485-49-4 - Calbiochem

505875
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₇NO₆ 485-49-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05875.0001
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 50 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
          Catalogue Number505875
          Brand Family Calbiochem®
          SynonymsGABAA Receptor Antagonist, Bicuculline
          References
          ReferencesUeno, S., et al. 1997. J. Neurosci. 17, 625.
          Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
          Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
          Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.
          Product Information
          CAS number485-49-4
          FormPale yellow solid
          Hill FormulaC₂₀H₁₇NO₆
          Chemical formulaC₂₀H₁₇NO₆
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGABAA
          Primary Target IC<sub>50</sub>740 Nm
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23-24-28-46

          Toxic by inhalation.
          Toxic in contact with skin.
          Very toxic if swallowed.
          May cause heritable genetic damage.
          S PhraseS: 22-28.1-36/37/39

          Do not breathe dust.
          After contact with skin, wash immediately with plenty of water.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Ueno, S., et al. 1997. J. Neurosci. 17, 625.
          Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
          Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
          Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-September-2013 JSW
          SynonymsGABAA Receptor Antagonist, Bicuculline
          DescriptionA potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
          FormPale yellow solid
          CAS number485-49-4
          Chemical formulaC₂₀H₁₇NO₆
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesUeno, S., et al. 1997. J. Neurosci. 17, 625.
          Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
          Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
          Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.