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376820 | β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem

376820
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₁N₃O₄ • 1/2(CH₃OH) 281224-40-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      376820-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable bisnaphthalimide compound that acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 and 3.1 µM for hHex A and hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN. Shown to function as a pharmacological chaperone and effectively enhance the transport of mutant Hex alpha subunit from the ER to lysosome in cells derived from ISD and ATSD patients.
          Catalogue Number376820
          Brand Family Calbiochem®
          SynonymsM-31850
          References
          ReferencesTropak, M.B., et al. 2007. Chem. Biol. 14, 153.
          Product Information
          CAS number281224-40-6
          FormWhite solid
          Hill FormulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
          Chemical formulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
          Structure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at 20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          376820

          References

          Reference overview
          Tropak, M.B., et al. 2007. Chem. Biol. 14, 153.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsM-31850
          DescriptionA cell-permeable bisnaphthalimide compound that acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 & 3.1 µM for hHex A & hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN. Shown to function as a pharmacological chaperone and effectively enhance the transport of mutant Hex alpha subunit from the ER to lysosome in cells derived from ISD and ATSD patients.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Recommended reaction conditions
          Please Note: DMSO is known to exhibit inhibitory effects against hexosaminidase, therefore it is essential to include proper vehicle controls if a hexosaminidase inhibitor stock prepared in DMSO is used in studies involving hexosaminidase.
          CAS number281224-40-6
          Chemical formulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at 20°C.
          Toxicity Standard Handling
          ReferencesTropak, M.B., et al. 2007. Chem. Biol. 14, 153.