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345868 | [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem

345868
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₂₆O₄ 23513-14-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345868-5MG
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          Glass bottle 5 mg
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          Description
          OverviewAn antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum (EC50 = 4 µM) and increases Ca2+ uptake.
          Catalogue Number345868
          Brand Family Calbiochem®
          Synonyms1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone
          References
          ReferencesBode, A.M., et al. 2001. Cancer Res. 61, 850.
          Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
          Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
          Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.
          Product Information
          CAS number23513-14-6
          ATP CompetitiveN
          FormPale yellow oil
          Hill FormulaC₁₇H₂₆O₄
          Chemical formulaC₁₇H₂₆O₄
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetActivator Protein-1 (AP-1)
          Primary Target IC<sub>50</sub>EC50 = 4 µM increasing the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSHE0757000
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345868

          References

          Reference overview
          Bode, A.M., et al. 2001. Cancer Res. 61, 850.
          Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
          Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
          Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-June-2008 RFH
          Synonyms1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone
          DescriptionPhytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (EC50 = 4 µM).
          FormPale yellow oil
          Intert gas (Yes/No) Packaged under inert gas
          CAS number23513-14-6
          RTECSHE0757000
          Chemical formulaC₁₇H₂₆O₄
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.
          Toxicity Harmful
          ReferencesBode, A.M., et al. 2001. Cancer Res. 61, 850.
          Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
          Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
          Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.