Neurodegenerative Diseases

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Featured Antibody
Anti-APP A4 Antibody, a.a. 66-81 of APP , clone 22C11

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Immunostaining of Alzheimer’s Disease hypothalamus tissue using Anti-APP A4 Antibody, a.a. 66-81 of APP , clone 22C11 (Catalog No. MAB348). Immunoreactivity is seen as dark brown staining on plaque deposits. High mag.
Neurodegenerative diseases are characterized by deterioration of neurons or their myelin sheath, disrupting transmission of sensory information, movement control, and more. Because these cells are not easily regenerated, buildup of amyloid plaques can lead to disorders such as Alzheimer’s and Parkinson’s disease, and non-amyloid-related degeneration can cause amyotrophic lateral sclerosis and multiple sclerosis. MilliporeSigma offers antibodies and analytically validated neurodegeneration and neurological disease biomarkers for elucidating the pathogenesis of both amyloid and non-amyloid-related neurodegeneration, aiding early diagnosis and providing therapeutic tools.

Neurodegenerative Disease with Targets
Learn about featured antibodies for neurodegenerative and neurological diseases including:
Alzheimer's Disease
Key Targets:
Alzheimer’s Disease is characterized by neuronal loss, alterations in neurotransmitter systems, and the presence of neurofibrillary tangles composed of abnormal tau paired helical filaments.
Huntington's Disease
Key Targets:
Huntington's Disease (HD) is a devastating, hereditary, degenerative brain disorder for which there is, at present, no effective treatment or cure. Huntington’s Disease slowly diminishes the affected individual’s ability.
Parkinson's Disease
Key Targets:
Parkinson’s Disease is a degenerative disorder of the central nervous system that occurs when cells in an area of the brain called the substantia nigra begin to malfunction and die.
Multiple Sclerosis (MS)
Key Targets:
Multiple Sclerosis (MS) is a nerve disorder caused by the autoimmune destruction of the insulating myelin layer surrounding neurons in the brain and spinal cord.
Acute Injury and Chronic Neurodegeneration
Key Targets:
A general feature of many neurological diseases, disorders, or injuries is the degeneration of proximal and/or distal neural processes.
Brain Inflammation
Key Targets:
Whether a massive inflammatory response caused by head injury or a viral infection such as encephalitis or meningitis, or a localized event caused by neurodegenerative disease, inflammation of the central nervous system can cause serious additional neurological damage.
Reward Pathways & Addiction
Key Targets:
Americans view Drug abuse and addiction as the most serious public health problem, above cancer, heart disease, AIDS and even violence.
Prion Diseases
Key Targets:
The prion protein is a large membrane protein that occurs normally in neurons of the human brain and is thought to be involved in synaptic transmission.

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