Histone Citrullination

Citrullination is a modification of arginine thought to play a role in rheumatoid arthritis and multiple sclerosis. 10% of histones are citrullinated, suggesting that citrulline has a role in gene regulation. Millipore offers a site-specific antibody to citrullinated histone H4, as well as antibodies and assays to detect this unique amino acid.