Vaccines Learning Center

Filter Requirements

• For use in place of a bag filter or for extra clarification after cell lysis
• Multi-stage graded density design retains solids or sediment within the depth matrix
• Polypropylene media provides excellent solids capacity and high throughput.

Filter Requirements

• For use in series after the Polygard® CR filter when no bag filter is used for solids removal
• Polypropylene graded density prefilter for robust particle and colloid removal
• 1–2 log bioburden reduction
• Validated for multiple sanitization and SIP cycles
• Higher filtrate quality allows smaller size requirements for downstream sterilizing-grade filtration step
• Non-fiber releasing structure preserves product purity.

Filter Requirements

• Low feed flow requirement minimizes pumping, working and hold up volumes
• Highly retentive regenerated cellulose membranes offer good permeate flux and withstand process upsets
• Robust low binding void-free Ultracel® PLC membranes assure consistent processing from batch to batch, have good chemical compatibility and are easy to clean
• Complete range of devices for easy scale-up
• Choose a membrane molecular weight cut-off 3–5X smaller than the biomolecule. Choice should be based on small-scale testing.

Filter Requirements

• Low feed flow requirement minimizes pumping, working and hold up volumes
• Higher product recovery and flux
• Highly retentive regenerated cellulose membranes offer good permeate flux and withstand process upsets
• Robust low binding void-free Ultracel® PLC membranes assure consistent processing from batch to batch, have good chemical compatibility and are easy to clean
• Complete range of devices for easy scale-up
• Choose a membrane molecular weight cut-off 3–5X smaller than the biomolecule. Choice should be based on small-scale testing.

Filter Requirements

• Sterilizing-grade PES 0.2 µm membrane with an additional 0.5 µm PES prefilter layer all in one pleated device
• Double-layer construction provides excellent capacity even in high salt conditions
• PES membrane provides broad chemical compatibility across a wide pH range (1–14)
• Robust construction validated for multiple SIP cycles
• 100% integrity tested to ensure quality
• Asymmetric PES pore structure delivers extremely high flow rates at low pressure drop
• Can be integrity tested on-site