554720 trans-Retinoic Acid - CAS 302-79-4 - Calbiochem

554720
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₈O₂ 302-79-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      554720-500MG
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          Glass bottle 500 mg
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          Description
          OverviewPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells. PROTECT FROM AIR.
          Catalogue Number554720
          Brand Family Calbiochem®
          SynonymsTretinoin, ATRA, Vitamin A Acid
          References
          ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
          Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
          Labbaye, C., et al. 1993. Blood 81, 475.
          Sakashita, A., et al. 1993. Blood 81, 1009.
          Situ, R., et al. 1993. Dermatology 186, 38.
          Tini, M., et al. 1993. Genes Develop. 7, 295.
          Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
          Sharpe, C.R. 1991. Neuron 7, 239.
          Thaller, C. and Eichele, G. 1990. Nature 345, 815.
          Product Information
          CAS number302-79-4
          FormYellow solid
          Hill FormulaC₂₀H₂₈O₂
          Chemical formulaC₂₀H₂₈O₂
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by assay
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSVH6475000
          Safety Information
          R PhraseR: 22-36/37/38-63

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          Possible risk of harm to the unborn child.
          S PhraseS: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          trans-Retinoic Acid - CAS 302-79-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          trans-Retinoic Acid - CAS 302-79-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          554720

          References

          Reference overview
          Tosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
          Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
          Labbaye, C., et al. 1993. Blood 81, 475.
          Sakashita, A., et al. 1993. Blood 81, 1009.
          Situ, R., et al. 1993. Dermatology 186, 38.
          Tini, M., et al. 1993. Genes Develop. 7, 295.
          Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
          Sharpe, C.R. 1991. Neuron 7, 239.
          Thaller, C. and Eichele, G. 1990. Nature 345, 815.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-October-2007 RFH
          SynonymsTretinoin, ATRA, Vitamin A Acid
          DescriptionPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number302-79-4
          RTECSVH6475000
          Chemical formulaC₂₀H₂₈O₂
          Structure formulaStructure formula
          Purity≥95% by assay
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 8165
          ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
          Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
          Labbaye, C., et al. 1993. Blood 81, 475.
          Sakashita, A., et al. 1993. Blood 81, 1009.
          Situ, R., et al. 1993. Dermatology 186, 38.
          Tini, M., et al. 1993. Genes Develop. 7, 295.
          Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
          Sharpe, C.R. 1991. Neuron 7, 239.
          Thaller, C. and Eichele, G. 1990. Nature 345, 815.