506157 p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem

506157
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₅NO₂S 349087-34-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506157-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable piperidinamide compound that acts as a reversible and highly potent inhibitor of MAPK p38α (IC50 = 32 nM) with no detectable activity against p38γ even at concentrations as high as 10 µM. Shown to effectively block the differentiation of L8 myoblasts to myotubes at 10 µM in a reversible manner. Not a competitive inhibitor with respect to either ATP or substrate.
          Catalogue Number506157
          Brand Family Calbiochem®
          SynonymsN-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine
          References
          ReferencesFriedmann, Y., et al. 2006. Mol. Pharmacol. 70, 1395.
          Product Information
          CAS number349087-34-9
          FormOff-white solid
          Hill FormulaC₂₁H₂₅NO₂S
          Chemical formulaC₂₁H₂₅NO₂S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506157

          References

          Reference overview
          Friedmann, Y., et al. 2006. Mol. Pharmacol. 70, 1395.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-February-2008 JSW
          SynonymsN-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine
          DescriptionA cell-permeable piperidinamide compound that acts as a reversible and highly potent inhibitor of MAPK p38α (IC50 = 32 nM) with no detectable activity against p38γ even at concentrations as high as 10 µM. Shown to effectively block the differentiation of L8 myoblasts to myotubes at 10 µM in a reversible manner. Not a competitive inhibitor with respect to either ATP or substrate.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number349087-34-9
          Chemical formulaC₂₁H₂₅NO₂S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (26 mg/ml) or Ethanol (17 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesFriedmann, Y., et al. 2006. Mol. Pharmacol. 70, 1395.