506153 | p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem

506153
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₄Cl₆O₄S 1638-41-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506153-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).
          Catalogue Number506153
          Brand Family Calbiochem®
          Synonyms2,2ʹ-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4
          References
          ReferencesLiu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun. 352, 656.
          Product Information
          CAS number1638-41-1
          FormLight yellow solid
          Hill FormulaC₁₂H₄Cl₆O₄S
          Chemical formulaC₁₂H₄Cl₆O₄S
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-37/38-41

          Harmful if swallowed.
          Irritating to respiratory system and skin.
          Risk of serious damage to eyes.
          S PhraseS: 26-39

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506153

          References

          Reference overview
          Liu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun. 352, 656.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-May-2009 RFH
          Synonyms2,2ʹ-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4
          DescriptionA cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1638-41-1
          Chemical formulaC₁₂H₄Cl₆O₄S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (4.5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesLiu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun. 352, 656.