178281 p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem

178281
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #
      74938-88-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178281-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewAlternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.
          Catalogue Number178281
          Brand Family Calbiochem®
          Synonymsp-Amidinophenylmethylsulfonylfluoride, HCl
          References
          ReferencesCole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
          Laura, R., et al. 1980. Biochemistry 19, 4859.
          Product Information
          CAS number74938-88-8
          ATP CompetitiveN
          FormWhite solid
          ReversibleN
          Applications
          Biological Information
          Primary Targettrypsin-like serine proteases
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          178281

          References

          Reference overview
          Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
          Laura, R., et al. 1980. Biochemistry 19, 4859.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2008 RFH
          Synonymsp-Amidinophenylmethylsulfonylfluoride, HCl
          DescriptionAn alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.
          FormWhite solid
          CAS number74938-88-8
          Purity≥97% by HPLC
          SolubilityH₂O (25 mg/ml)
          Storage +2°C to +8°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Standard Handling
          ReferencesCole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
          Laura, R., et al. 1980. Biochemistry 19, 4859.