445865 mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem

445865
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₁₆N₄O 781652-57-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      445865-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Also exerts anti-psychotic-like effects. Reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR5 cells (EC50 = 10 nM for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation) and reverse amphetamine-induced disruption of pre-pulse inhibition (PPI) in rats. Specificity was determined using a panel of kinases and receptors. Does not potentiate the activity of other glutamate receptors.
          Catalogue Number445865
          Brand Family Calbiochem®
          Synonyms3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
          References
          ReferencesKinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
          Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.
          Product Information
          CAS number781652-57-1
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₃H₁₆N₄O
          Chemical formulaC₂₃H₁₆N₄O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMetabotropic glutamate receptor subtype 5 (mGluR5)
          Primary Target IC<sub>50</sub>EC50 = 10 nM in potentiating the response to glutamate (~300 nM) in CHO-mGluR5 cells for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          445865

          References

          Reference overview
          Kinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
          Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
          DescriptionA pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Also exerts anti-psychotic-like effects. Reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR5 cells (EC50 = 10 nM for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation) and reverse amphetamine-induced disruption of pre-pulse inhibition (PPI) in rats. Specificity was determined using a panel of kinases and receptors. Does not potentiate the activity of other glutamate receptors.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number781652-57-1
          Chemical formulaC₂₃H₁₆N₄O
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
          Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.