344036 | cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

344036
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₂N₄O₃ 870483-87-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344036-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available.
          Catalogue Number344036
          Brand Family Calbiochem®
          Synonyms5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
          References
          ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
          Product Information
          CAS number870483-87-7
          ATP CompetitiveY
          FormOff-white solid
          Hill FormulaC₂₀H₂₂N₄O₃
          Chemical formulaC₂₀H₂₂N₄O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCFMS
          Primary Target IC<sub>50</sub>30 nM against cFMS kinase activity
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344036

          References

          Reference overview
          Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-June-2010 JSW
          Synonyms5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
          DescriptionA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number870483-87-7
          Chemical formulaC₂₀H₂₂N₄O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.