475958 | c-Raf Inhibitor - Calbiochem

475958
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₁₉F₃N₈O

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475958-20MG
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          Glass bottle 20 mg
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          Description
          OverviewA cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µM) and WM3629 (GI50 = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
          Catalogue Number475958
          Brand Family Calbiochem®
          Synonyms1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea, c-Raf Inhibitor
          References
          ReferencesYu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805.
          Product Information
          FormOff white solid
          Hill FormulaC₂₃H₁₉F₃N₈O
          Chemical formulaC₂₃H₁₉F₃N₈O
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475958

          References

          Reference overview
          Yu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-June-2011 RFH
          Synonyms1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea, c-Raf Inhibitor
          DescriptionA cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µM) and WM3629 (GI50 = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
          FormOff white solid
          Chemical formulaC₂₃H₁₉F₃N₈O
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805.