203694 | bpV(bipy) - Calbiochem

203694
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      K[VO(O₂)₂C₁₀H₈N₂] · 3H₂O

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203694-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC50 = 18 nM).
          Catalogue Number203694
          Brand Family Calbiochem®
          SynonymsPotassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
          References
          ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
          Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
          Product Information
          ATP CompetitiveN
          FormYellow to orange solid
          Hill FormulaK[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
          Chemical formulaK[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetphosphotyrosine phosphatase
          Primary Target IC<sub>50</sub>18 nM against PTEN
          Primary Target K<sub>i</sub>100 nM for phosphotyrosine phosphatase
          Purity≥95% by ⁵¹V-NMR
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203694

          References

          Reference overview
          Schmid, A.C., et al. 2004. FEBS Lett. 566, 35.
          Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

          Brochure

          Title
          Protein Phosphatases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-May-2008 RFH
          SynonymsPotassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
          DescriptionA potent inhibitor of phosphotyrosine phosphatase activity (Ki = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC50 = 18 nM).
          FormYellow to orange solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaK[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
          Structure formulaStructure formula
          Purity≥95% by ⁵¹V-NMR
          SolubilityH₂O (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Harmful
          ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
          Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.