504777 | Yohimbine Hydrochloride - CAS 65-19-0 - Calbiochem

504777
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₆N₂O₃ • HCl 65-19-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04777.0001
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          Glass bottle 1 gm
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          Description
          OverviewA potent antagonist for α2-adrenoceptors (pKi values are 8.52, 8.00 and 9.17 for human α2a, α2B and α2C receptors respectively). Often used as pharmacological stressor in animal studies.
          Catalogue Number504777
          Brand Family Calbiochem®
          Synonyms17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride, α₂-Adrenoceptor Antagonist, Yohimbine Hydrochloride
          References
          ReferencesCalu, D., et al. 2013. J. Neurosci. 33, 214.
          Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol. 325, 136.
          Goldberg, K., et al. 1987. Pharmacol. Rev. 35, 143.
          Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther. 303, 979.
          Product Information
          CAS number65-19-0
          FormPale yellow solid
          Hill FormulaC₂₁H₂₆N₂O₃ • HCl
          Chemical formulaC₂₁H₂₆N₂O₃ • HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target→₂-adrenoceptor
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25

          Toxic if swallowed.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°c). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Calu, D., et al. 2013. J. Neurosci. 33, 214.
          Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol. 325, 136.
          Goldberg, K., et al. 1987. Pharmacol. Rev. 35, 143.
          Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther. 303, 979.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-July-2013 JSW
          Synonyms17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride, α₂-Adrenoceptor Antagonist, Yohimbine Hydrochloride
          DescriptionA potent antagonist for α2-adrenoceptors (pKi values are 8.52, 8.00 and 9.17 for human α2a, α2B and α2C receptors respectively). Often used as pharmacological stressor in animal studies.
          FormPale yellow solid
          CAS number65-19-0
          Chemical formulaC₂₁H₂₆N₂O₃ • HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (25 mM). Slight warming is required for complete solubilization.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°c). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesCalu, D., et al. 2013. J. Neurosci. 33, 214.
          Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol. 325, 136.
          Goldberg, K., et al. 1987. Pharmacol. Rev. 35, 143.
          Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther. 303, 979.