681673 Wnt Antagonist III, Box5 - Calbiochem

681673
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₀H₅₀N₆O₁₃S₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      681673-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
          Catalogue Number681673
          Brand Family Calbiochem®
          SynonymsWnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist
          References
          ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
          Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
          Product Information
          FormWhite lyophilized solid
          Hill FormulaC₃₀H₅₀N₆O₁₃S₂
          Chemical formulaC₃₀H₅₀N₆O₁₃S₂
          Applications
          ApplicationWnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.
          Biological Information
          Purity≥90% by HPLC
          Physicochemical Information
          Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Wnt Antagonist III, Box5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Wnt Antagonist III, Box5 - Calbiochem Certificates of Analysis

          TitleLot Number
          681673

          References

          Reference overview
          Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
          Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-December-2010 RFH
          SynonymsWnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist
          DescriptionA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
          FormWhite lyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₀H₅₀N₆O₁₃S₂
          Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
          Purity≥90% by HPLC
          SolubilityDMSO (50 mg/ml) or H₂O (4 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
          Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.