681665 Wnt Agonist - CAS 853220-52-7 - Calbiochem

681665
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₈N₄O₃ 853220-52-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      681665-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC50 > 60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).
          Catalogue Number681665
          Brand Family Calbiochem®
          Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
          References
          ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
          Product Information
          CAS number853220-52-7
          ATP CompetitiveN
          FormYellowish sticky solid
          Hill FormulaC₁₉H₁₈N₄O₃
          Chemical formulaC₁₉H₁₈N₄O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationWnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).
          Biological Information
          Primary TargetSelective activator of Wnt signaling
          Primary Target IC<sub>50</sub>EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Wnt Agonist - CAS 853220-52-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Wnt Agonist - CAS 853220-52-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          681665

          References

          Reference overview
          Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
          DescriptionA cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50 >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development.
          FormYellowish sticky solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number853220-52-7
          Chemical formulaC₁₉H₁₈N₄O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.