508146 | WAY-100635 Maleate - CAS 634908-75-1 - Calbiochem

508146
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₃₄N₄O₂·C₄H₄O₄ 634908-75-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08146.0001
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          Glass bottle 10 mg
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          Description
          OverviewA selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
          Catalogue Number508146
          Brand Family Calbiochem®
          Synonyms5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
          References
          ReferencesHunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
          Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
          Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
          Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.
          Product Information
          CAS number634908-75-1
          FormOff-white solid
          Hill FormulaC₂₅H₃₄N₄O₂·C₄H₄O₄
          Chemical formulaC₂₅H₃₄N₄O₂·C₄H₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT1A
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Hunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
          Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
          Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
          Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-October-2013 JSW
          Synonyms5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
          DescriptionA selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
          FormOff-white solid
          CAS number634908-75-1
          Chemical formulaC₂₅H₃₄N₄O₂·C₄H₄O₄
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityH₂O (50 mM). Warming is required for complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
          Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
          Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
          Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.