681629 W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem

681629
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₂₁ClN₂O₂S · HCl 61714-27-0

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      681629-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).
          Catalogue Number681629
          Brand Family Calbiochem®
          SynonymsN-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl
          References
          ReferencesCaulfield, M.P., et al. 1991. Neurosci. Lett. 125, 57.
          Asano, M. 1989. J. Pharmacol. Exp. Ther. 251, 764.
          Itoh, H., and Hidaka, H. 1984. J. Biochem. 96, 1721.
          Tanaka, T., et al. 1983. Pharmacol. 26, 249.
          Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.
          Product Information
          CAS number61714-27-0
          ATP CompetitiveN
          FormOff-white crystalline solid
          Hill FormulaC₁₆H₂₁ClN₂O₂S · HCl
          Chemical formulaC₁₆H₂₁ClN₂O₂S · HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMyosin light chain kinase
          Primary Target IC<sub>50</sub> 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQK0786000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          681629

          References

          Reference overview
          Caulfield, M.P., et al. 1991. Neurosci. Lett. 125, 57.
          Asano, M. 1989. J. Pharmacol. Exp. Ther. 251, 764.
          Itoh, H., and Hidaka, H. 1984. J. Biochem. 96, 1721.
          Tanaka, T., et al. 1983. Pharmacol. 26, 249.
          Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-January-2010 RFH
          SynonymsN-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl
          DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM) and myosin light chain kinase (IC50 = 51 µM).
          FormOff-white crystalline solid
          CAS number61714-27-0
          RTECSQK0786000
          Chemical formulaC₁₆H₂₁ClN₂O₂S · HCl
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (5 mg/ml), DMF, or warm Ethanol
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Standard Handling
          ReferencesCaulfield, M.P., et al. 1991. Neurosci. Lett. 125, 57.
          Asano, M. 1989. J. Pharmacol. Exp. Ther. 251, 764.
          Itoh, H., and Hidaka, H. 1984. J. Biochem. 96, 1721.
          Tanaka, T., et al. 1983. Pharmacol. 26, 249.
          Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors