681636 W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem

681636
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₇ClN₂O₂S . HCl 88519-57-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      681636-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).
          Catalogue Number681636
          Brand Family Calbiochem®
          SynonymsN-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
          References
          ReferencesHidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
          Tanaka, T., et al. 1983. Pharmacol. 26, 249.
          Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
          Product Information
          CAS number88519-57-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₄H₁₇ClN₂O₂S . HCl
          Chemical formulaC₁₄H₁₇ClN₂O₂S . HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetmlck
          Primary Target IC<sub>50</sub>58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase
          Purity≥98% by HPLC and single spot by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          681636

          References

          Reference overview
          Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
          Tanaka, T., et al. 1983. Pharmacol. 26, 249.
          Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-January-2010 RFH
          SynonymsN-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
          DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).
          FormWhite solid
          CAS number88519-57-7
          Chemical formulaC₁₄H₁₇ClN₂O₂S . HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC and single spot by TLC
          SolubilityH₂O (35 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Standard Handling
          ReferencesHidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
          Tanaka, T., et al. 1983. Pharmacol. 26, 249.
          Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors