677175 Vinblastine Sulfate - CAS 143-67-9 - Calbiochem

677175
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₆H₅₈N₄O₉ · H₂SO₄ 143-67-9

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      677175-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewAntitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases frequency of micronucleated erythrocytes.
          Catalogue Number677175
          Brand Family Calbiochem®
          References
          ReferencesTanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
          Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
          Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
          Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
          Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
          Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
          Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
          Prasad, V., et al. 1992. J. Protein Chem. 11, 509.
          Product Information
          CAS number143-67-9
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₄₆H₅₈N₄O₉ · H₂SO₄
          Chemical formulaC₄₆H₅₈N₄O₉ · H₂SO₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInteraction of tubulin with microtubule-associated proteins, specifically Tau and MAP2
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYY8400000
          Safety Information
          R PhraseR: 22-37/38-61-41

          Harmful if swallowed.
          Irritating to respiratory system and skin.
          May cause harm to the unborn child.
          Risk of serious damage to eyes.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Vinblastine Sulfate - CAS 143-67-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Vinblastine Sulfate - CAS 143-67-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          677175

          References

          Reference overview
          Tanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
          Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
          Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
          Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
          Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
          Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
          Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
          Prasad, V., et al. 1992. J. Protein Chem. 11, 509.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-July-2014 JSW
          DescriptionAntitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases the frequency of micronucleated erythrocytes.
          FormWhite crystalline solid
          CAS number143-67-9
          RTECSYY8400000
          Chemical formulaC₄₆H₅₈N₄O₉ · H₂SO₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (50 mg/ml)
          Storage +2°C to +8°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 9982
          ReferencesTanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
          Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
          Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
          Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
          Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
          Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
          Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
          Prasad, V., et al. 1992. J. Protein Chem. 11, 509.