662088 UCH-L1 Inhibitor II - CAS 439946-22-2 - Calbiochem

662088
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀N₂O₄S 439946-22-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      662088-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA thienopyridinone compound that inhibits UCH-L1-catalyzed substrate hydrolysis (Ki app = 2.8 µM with Ub-AMC as the substrate) in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme, while exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 µM.
          Catalogue Number662088
          Brand Family Calbiochem®
          SynonymsUbiquitin C-terminal Hydrolase-L1 Inhibitor II, 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid, LDN-91946
          References
          ReferencesMermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3729.
          Product Information
          CAS number439946-22-2
          FormBrown solid
          Hill FormulaC₁₅H₁₀N₂O₄S
          Chemical formulaC₁₅H₁₀N₂O₄S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥85% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          UCH-L1 Inhibitor II - CAS 439946-22-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          UCH-L1 Inhibitor II - CAS 439946-22-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          662088

          References

          Reference overview
          Mermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3729.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          SynonymsUbiquitin C-terminal Hydrolase-L1 Inhibitor II, 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid, LDN-91946
          DescriptionA thienopyridinone compound that inhibits UCH-L1-catalyzed substrate hydrolysis (Ki app = 2.8 µM with Ub-AMC as the substrate) in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme, while exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 µM.
          FormBrown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number439946-22-2
          Chemical formulaC₁₅H₁₀N₂O₄S
          Structure formulaStructure formula
          Purity≥85% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesMermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3729.