648469 Troglitazone - CAS 97322-87-7 - Calbiochem

648469
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₇NO₅S 97322-87-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      648469-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMC) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21Cip1 turnover by inhibiting PKCδ signaling in VSMCs. Exerts positive inotropic effect via Ca2+ sensitization in the sarcoplasmic reticulum and inhibits Na+/H+ exchange activity and proliferation of macrovascular endothelial cells.
          Catalogue Number648469
          Brand Family Calbiochem®
          References
          ReferencesMasamune, A., et al. 2002. J. Biol. Chem. 277, 141.
          Boyault, S., et al. 2001. FEBS Lett. 501, 24.
          de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120.
          Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307.
          Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306.
          Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909.
          Koga, H., et al. 2001. Hepatology 33, 1087.
          Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731.
          Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440.
          Takashima, T., et al. 2001. Int. J. Oncol. 19, 465.
          Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950.
          Tanaka, T., et al. 2001. Cancer Res. 61, 2424.
          Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.
          Product Information
          CAS number97322-87-7
          ATP CompetitiveN
          FormWhite to yellow solid
          Hill FormulaC₂₄H₂₇NO₅S
          Chemical formulaC₂₄H₂₇NO₅S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPeroxisome proliferator-activated receptors γ (PPARγ)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSXJ5813130
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Troglitazone - CAS 97322-87-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Troglitazone - CAS 97322-87-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          648469

          References

          Reference overview
          Masamune, A., et al. 2002. J. Biol. Chem. 277, 141.
          Boyault, S., et al. 2001. FEBS Lett. 501, 24.
          de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120.
          Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307.
          Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306.
          Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909.
          Koga, H., et al. 2001. Hepatology 33, 1087.
          Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731.
          Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440.
          Takashima, T., et al. 2001. Int. J. Oncol. 19, 465.
          Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950.
          Tanaka, T., et al. 2001. Cancer Res. 61, 2424.
          Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-March-2018 JSW
          DescriptionA α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMCs) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21cip1 turnover by inhibiting PKCδ signaling in VSMCs. Exerts positive inotropic effect via Ca2+ sensitization in sarcoplasmic reticulum and inhibits Na+/H+ change activity.
          FormWhite to yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number97322-87-7
          RTECSXJ5813130
          Chemical formulaC₂₄H₂₇NO₅S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or ethanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMasamune, A., et al. 2002. J. Biol. Chem. 277, 141.
          Boyault, S., et al. 2001. FEBS Lett. 501, 24.
          de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120.
          Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307.
          Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306.
          Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909.
          Koga, H., et al. 2001. Hepatology 33, 1087.
          Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731.
          Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440.
          Takashima, T., et al. 2001. Int. J. Oncol. 19, 465.
          Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950.
          Tanaka, T., et al. 2001. Cancer Res. 61, 2424.
          Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.