647950 Triclosan - CAS 3380-34-5 - Calbiochem

647950
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₇Cl₃O₂ 3380-34-5

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      647950-1GM
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          Glass bottle 1 gm
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          Description
          OverviewA potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase. A slow-binding inhibitor that forms a stable ternary complex (bsFabl.NAD+.triclosan) in Bacillus subtilis.
          Catalogue Number647950
          Brand Family Calbiochem®
          Synonyms5-Chloro-2-(2,4-dichlorophenoxy)phenol
          References
          ReferencesMcLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
          Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
          Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
          Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
          Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
          Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
          McMurray, L.M., et al. 1998. Nature 394, 531.
          Product Information
          CAS number3380-34-5
          FormWhite powder or crystalline powder
          Hill FormulaC₁₂H₇Cl₃O₂
          Chemical formulaC₁₂H₇Cl₃O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSKO1100000
          Safety Information
          R PhraseR: 36/37/38-50/53

          Irritating to eyes, respiratory system and skin.
          Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
          S PhraseS: 26-36/39-46-60-61

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing and eye/face protection.
          If swallowed, seek medical advice immediately and show this container or label.
          This material and its container must be disposed of as hazardous waste.
          Avoid release to the environment. Refer to special instructions/safety data sheet.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Environmental Hazard
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Triclosan - CAS 3380-34-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Triclosan - CAS 3380-34-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          647950

          References

          Reference overview
          McLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
          Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
          Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
          Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
          Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
          Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
          McMurray, L.M., et al. 1998. Nature 394, 531.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-July-2019 JSW
          Synonyms5-Chloro-2-(2,4-dichlorophenoxy)phenol
          DescriptionA potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fab l encoded enoyl-acyl carrier protein (ACP) reductase. A slow binding inhibitor that forms a stable ternary complex (bsFabl.NAD+. triclosan) in Bacillus subtilis. Also inhibits the growth of Plasmodium falciparum by inhibiting the apicomplexan Fab I (IC50 = 154.4 ng/ml for W2 strain and 387 ng/ml for D6 strain).
          FormWhite powder or crystalline powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number3380-34-5
          RTECSKO1100000
          Chemical formulaC₁₂H₇Cl₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityAqueous NaOH
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Environmental Hazard
          ReferencesMcLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
          Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
          Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
          Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
          Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
          Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
          McMurray, L.M., et al. 1998. Nature 394, 531.