382425 | Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem

382425
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₇N₃O₃ · HCl 78416-81-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      382425-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewExtremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
          Catalogue Number382425
          Brand Family Calbiochem®
          Synonyms9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
          References
          ReferencesSpina, D., et al. 1998. Life Sci. 62, 953.
          Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
          Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
          Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
          Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
          DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
          Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
          Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.
          Product Information
          CAS number78416-81-6
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₂₄H₂₇N₃O₃ · HCl
          Chemical formulaC₂₄H₂₇N₃O₃ · HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetcGMP-inhibited phosphodiesterase
          Primary Target IC<sub>50</sub>300 pM against cGMP-inhibited phosphodiesterase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUW7727000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          382425

          References

          Reference overview
          Spina, D., et al. 1998. Life Sci. 62, 953.
          Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
          Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
          Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
          Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
          DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
          Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
          Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-July-2008 RFH
          Synonyms9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
          DescriptionExtremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
          FormPale yellow solid
          CAS number78416-81-6
          RTECSUW7727000
          Chemical formulaC₂₄H₂₇N₃O₃ · HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (500 µM)
          Storage +15°C to +30°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSpina, D., et al. 1998. Life Sci. 62, 953.
          Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
          Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
          Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
          Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
          DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
          Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
          Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.