616373 Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

616373
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₁₄ClFN₆ 871307-18-5

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      616373-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).
          Catalogue Number616373
          Brand Family Calbiochem®
          Synonyms4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
          References
          ReferencesGavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.
          Product Information
          CAS number871307-18-5
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₂₁H₁₄ClFN₆
          Chemical formulaC₂₁H₁₄ClFN₆
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationTpl2 Kinase Inhibitor, CAS 871307-18-5, is a cell-permeable, potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM).
          Biological Information
          Primary TargetTpl2 Kinase
          Primary Target IC<sub>50</sub>50 nM against Tpl2 kinase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          616373

          References

          Reference overview
          Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-October-2007 JSW
          Synonyms4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
          DescriptionA cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number871307-18-5
          Chemical formulaC₂₁H₁₄ClFN₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesGavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.