554412 Tetrodotoxin, Citrate, Fugu sp. - CAS 18660-81-6 - Calbiochem

554412
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      Overview

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      554412-1MG
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          Alu drum 1 mg
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          Description
          OverviewReversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
          Catalogue Number554412
          Brand Family Calbiochem®
          SynonymsTTx
          References
          ReferencesLysko, P.G., et al. 1994. Stroke 25, 2476.
          Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
          Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.
          Product Information
          CAS number18660-81-6
          ATP CompetitiveN
          DeclarationNot available for sale outside of the United States.
          FormWhite solid
          FormulationCrystalline solid. Contains sodium citrate.
          Hill FormulaC₁₁H₁₇N₃O₈
          Chemical formulaC₁₁H₁₇N₃O₈
          ReversibleY
          Applications
          ApplicationTetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.
          Biological Information
          Primary TargetNa+ channels
          Primary Target IC<sub>50</sub>63 nM Iinhibiting the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation
          Purity≥98%
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSIO1450000
          Safety Information
          R PhraseR: 28

          Very toxic if swallowed.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
          End use certificateY
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Tetrodotoxin, Citrate, Fugu sp. - CAS 18660-81-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Tetrodotoxin, Citrate, Fugu sp. - CAS 18660-81-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          554412

          References

          Reference overview
          Lysko, P.G., et al. 1994. Stroke 25, 2476.
          Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
          Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-August-2008 JSW
          SynonymsTTx
          DescriptionReversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
          FormWhite solid
          FormulationCrystalline solid. Contains sodium citrate.
          CAS number18660-81-6
          RTECSIO1450000
          Chemical formulaC₁₁H₁₇N₃O₈
          Purity≥98%
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
          Toxicity Highly Toxic
          Merck USA index14, 9246
          ReferencesLysko, P.G., et al. 1994. Stroke 25, 2476.
          Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
          Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.