509892 | Tetrabenazine, TBZ - CAS 58-46-8 - Calbiochem

509892
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₇NO₃ 58-46-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.09892.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number509892
          Brand Family Calbiochem®
          SynonymsVMAT2 Inhibitor, Xenazine
          References
          ReferencesSakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
          Jankovic, J., et al. 1997. Neurobiology 48,1358.
          Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.
          Product Information
          CAS number58-46-8
          FormOff-white powder
          Hill FormulaC₁₉H₂₇NO₃
          Chemical formulaC₁₉H₂₇NO₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetVMAT2
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 36-45

          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Sakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
          Jankovic, J., et al. 1997. Neurobiology 48,1358.
          Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-May-2014 JSW
          SynonymsVMAT2 Inhibitor, Xenazine
          DescriptionA cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number58-46-8
          Chemical formulaC₁₉H₂₇NO₃
          Purity≥98% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesSakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
          Jankovic, J., et al. 1997. Neurobiology 48,1358.
          Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.