500609 Temozolomide - CAS 85622-93-1 - Calbiochem

Temozolomide - CAS 85622-93-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 362856, 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide, CCRG 81045, TMZ, 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

Primary Target: DNA guanine residues
500609
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆H₆N₆O₂ 85622-93-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.00609.0001
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          		 Glass bottle 50 mg
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          Description
          OverviewA cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number500609
          Brand Family Calbiochem®
          SynonymsNSC 362856, 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide, CCRG 81045, TMZ, 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
          References
          ReferencesNeyns, B., et al. 2010. Cancer 116, 2868.
          Marchesi, F., et al. 2007. Pharmacol. Res. 56, 275.
          Chakravarti, A., et al. 2006. Clin. Cancer Res. 12, 4738.
          Natsume, A., et al. 2005. Cancer Res. 65, 7573.
          Jen, J.F., et al. 2000. Pharm. Res. 17, 1284.
          Product Information
          CAS number85622-93-1
          FormOff-white solid
          Hill FormulaC₆H₆N₆O₂
          Chemical formulaC₆H₆N₆O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA guanine residues
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23/24/25-36/37/38-45-46

          Toxic by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause cancer.
          May cause heritable genetic damage.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Neyns, B., et al. 2010. Cancer 116, 2868.
          Marchesi, F., et al. 2007. Pharmacol. Res. 56, 275.
          Chakravarti, A., et al. 2006. Clin. Cancer Res. 12, 4738.
          Natsume, A., et al. 2005. Cancer Res. 65, 7573.
          Jen, J.F., et al. 2000. Pharm. Res. 17, 1284.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-May-2013 JSW
          SynonymsNSC 362856, 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide, CCRG 81045, TMZ, 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
          DescriptionA cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number85622-93-1
          Chemical formulaC₆H₆N₆O₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesNeyns, B., et al. 2010. Cancer 116, 2868.
          Marchesi, F., et al. 2007. Pharmacol. Res. 56, 275.
          Chakravarti, A., et al. 2006. Clin. Cancer Res. 12, 4738.
          Natsume, A., et al. 2005. Cancer Res. 65, 7573.
          Jen, J.F., et al. 2000. Pharm. Res. 17, 1284.