581011 Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem

581011
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₆N₂O₆ 368449-04-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      581011-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 µM).
          Catalogue Number581011
          Brand Family Calbiochem®
          SynonymsMST-312, N,Nʹ-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine
          References
          ReferencesSeimiya, H., et al. 2005. Cancer Cell 7, 25.
          Seimiya, H., et al. 2002. Mol. Cancer Ther. 1, 657.
          Product Information
          CAS number368449-04-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₀H₁₆N₂O₆
          Chemical formulaC₂₀H₁₆N₂O₆
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTRAP lysate prepared from U937 cells
          Primary Target IC<sub>50</sub>670 nM against telomerase activity in TRAP lysate prepared from U937 cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          581011

          References

          Reference overview
          Seimiya, H., et al. 2005. Cancer Cell 7, 25.
          Seimiya, H., et al. 2002. Mol. Cancer Ther. 1, 657.