580551 Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem

580551
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₁H₆₆O₁₃ 109946-35-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      580551-50UG
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          Alu drum 50 μg
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          Description
          OverviewMixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC50 = 1 nM), protein phosphatase 2A (IC50 = 10 nM), and smooth muscle endogenous phosphatase (IC50 = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.
          Catalogue Number580551
          Brand Family Calbiochem®
          References
          ReferencesMcCluskey, A., et al. 2002. J. Med. Chem. 45, 1151.
          Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
          Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395.
          Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387.
          Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3.
          Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662.
          Suganuma, M., et al. 1992. Toxicon 30, 873.
          MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137.
          Magae, J., et al. 1989. J. Antibiot. 42, 1290.
          Product Information
          CAS number109946-35-2
          ATP CompetitiveN
          FormLyophilized thin film
          Hill FormulaC₄₁H₆₆O₁₃
          Chemical formulaC₄₁H₆₆O₁₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPP1
          Primary Target IC<sub>50</sub>1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSWX1000000
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



          From Catalog:
          Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"
          - removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          580551

          References

          Reference overview
          McCluskey, A., et al. 2002. J. Med. Chem. 45, 1151.
          Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
          Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395.
          Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387.
          Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3.
          Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662.
          Suganuma, M., et al. 1992. Toxicon 30, 873.
          MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137.
          Magae, J., et al. 1989. J. Antibiot. 42, 1290.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          DescriptionMixture of two isomers. Potent inhibitor of protein phosphatases and useful for studies involving protein phosphorylation. Inhibits protein phosphatase 1 (IC50 = 1 nM), protein phosphatase 2A (IC50 = 10 nM), and smooth muscle endogenous phosphatase (IC50 = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase.
          FormLyophilized thin film
          CAS number109946-35-2
          RTECSWX1000000
          Chemical formulaC₄₁H₆₆O₁₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityChloroform, ethanol, or methanol
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



          From Catalog:
          Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"
          - removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase
          Toxicity Highly Toxic
          ReferencesMcCluskey, A., et al. 2002. J. Med. Chem. 45, 1151.
          Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
          Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395.
          Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387.
          Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3.
          Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662.
          Suganuma, M., et al. 1992. Toxicon 30, 873.
          MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137.
          Magae, J., et al. 1989. J. Antibiot. 42, 1290.