533574 TRPML3 Activator, ML123 - Calbiochem

533574
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₂₃ClN₂O₃S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.33574.0001
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          Glass bottle 25 mg
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          Description
          OverviewA non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
          Catalogue Number533574
          Brand Family Calbiochem®
          Synonyms4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
          References
          ReferencesAntolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
          Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
          Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
          Grimm, C., et al. 2010. Chem. Biol. 17, 135.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₆H₂₃ClN₂O₃S
          Chemical formulaC₁₆H₂₃ClN₂O₃S
          ReversibleY
          Applications
          Biological Information
          Primary TargetTRPML3
          Purity≥92% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TRPML3 Activator, ML123 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
          Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
          Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
          Grimm, C., et al. 2010. Chem. Biol. 17, 135.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-July-2016 JSW
          Synonyms4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
          DescriptionA non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₆H₂₃ClN₂O₃S
          Purity≥92% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAntolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
          Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
          Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
          Grimm, C., et al. 2010. Chem. Biol. 17, 135.