616452 TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

616452
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₃N₅ 446859-33-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      616452-2MG
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          Glass bottle 2 mg
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          Description
          OverviewA cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158).
          Catalogue Number616452
          Brand Family Calbiochem®
          SynonymsALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
          References
          ReferencesGellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
          Ichida, J. K., et al. 2009. 5, 491.
          Product Information
          CAS number446859-33-2
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₁₇H₁₃N₅
          Chemical formulaC₁₇H₁₃N₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetALKS binding
          Primary Target IC<sub>50</sub>23 nM
          Secondary targetALK 5 auto phosphorylation (IC₅₀ = 4 nM)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          616452

          References

          Reference overview
          Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
          Ichida, J. K., et al. 2009. 5, 491.

          Citations

          Title
          Maherali N., and Hochedlinger, K., 2009. Current Biology 19, 1718.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          SynonymsALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
          DescriptionA cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16 µM).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number446859-33-2
          Chemical formulaC₁₇H₁₃N₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesGellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
          Ichida, J. K., et al. 2009. 5, 491.
          CitationMaherali N., and Hochedlinger, K., 2009. Current Biology 19, 1718.