574775 Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem

574775
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₅NO₃ 72741-87-8

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      574775-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewReversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
          Catalogue Number574775
          Brand Family Calbiochem®
          Synonyms(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
          References
          ReferencesMochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
          Elbein, A.D. 1983. Methods Enzymol. 98, 135.
          Product Information
          CAS number72741-87-8
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₈H₁₅NO₃
          Chemical formulaC₈H₁₅NO₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetLysosomal α-mannosidase
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          574775

          References

          Reference overview
          Mochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
          Elbein, A.D. 1983. Methods Enzymol. 98, 135.

          Citations

          Title
        • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          Synonyms(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
          DescriptionReversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
          FormWhite solid
          CAS number72741-87-8
          Chemical formulaC₈H₁₅NO₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (5 mg/ml), H₂O (1 mg/ml), or Chloroform
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Harmful
          ReferencesMochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
          Elbein, A.D. 1983. Methods Enzymol. 98, 135.
          Citation
        • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.